Journal
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volume 38, Issue 11, Pages 901-919Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770.2019.1625379
Keywords
Manganese complex; mefenamic acid; DNA interaction; intercalation
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Funding
- Razi University Research Center
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The interaction of the [Mn(mef)(2)(phen)H2O] complex in which mef is mefenamic acid drug and phen is 1,10 phenanthrolin ligand with calf thymus DNA (ct-DNA) was studied by using different spectroscopic methods, molecular docking and viscometery. The competitive fluorescence and UV-Vis absorption spectroscopy indicated that the complex interacted with ctDNA via intercalating binding mode with the binding constant of 1.16 x 10(4) Lmol(-1). The thermodynamic studies showed that the reaction between the complex and ctDNA is exothermic. Furthermore, the complex induced changes in DNA viscosity. Circular dichroism spectroscopy (CD) was employed to measure the conformational changes of ctDNA in the presence of the complex and verified intercalation binding mode. The molecular modeling results illustrated that the complex interacted via intercalation by relative binding energy of -28.45 kJ mol(-1).
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