Journal
NMR IN BIOMEDICINE
Volume 32, Issue 10, Pages -Publisher
WILEY
DOI: 10.1002/nbm.4112
Keywords
applications; cellular and molecular cancer imaging; applications; metastases; cancer; cancer; applications; cancer therapy responses; methods and engineering; cancer; MR spectroscopy (MRS) and spectroscopic imaging (MRSI) methods
Funding
- NCI NIH HHS [R01 CA134695, R01 CA213492, T32 CA193145, R01 CA213428, R01 CA154725] Funding Source: Medline
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Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which leads to elevated levels of phosphocholine and glycerophosphocholine in all types of cancer tested so far. Magnetic resonance spectroscopy applications have played a key role in detecting these elevated choline phospholipid metabolites. To date, the majority of cancer-related studies have focused on phosphocholine and the Kennedy pathway, which constitutes the biosynthesis pathway for membrane phosphatidylcholine. Fewer and more recent studies have reported on the importance of glycerophosphocholine in cancer. In this review article, we summarize the recent literature on glycerophosphocholine metabolism with respect to its cancer biology and its detection by magnetic resonance spectroscopy applications.
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