Journal
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
Volume 87, Issue -, Pages 52-59Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.niox.2019.03.002
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Funding
- DID-UACh [S-2017-48]
- Fonde de Innovacidn para la Competitividad [17-6]
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S-nitrosylation, the modification by nitric oxide of free sulfhydtyl groups in cysteines, has become an important regulatory mechanism in carcinogenesis and metastasis. S-nitrosylation of targets in tumor cells contributes to metastasis regulating epithelial to mesenchymal transition, migration and invasion. In the tumor environment, the role of S-nitrosylation in endothelium has not been addressed; however, the evidence points out that S-nitrosylation of endothelial proteins may regulate angiogenesis, adhesion of tumor cells to the endothelium, intra and extravasation of tumor cells and contribute to metastasis.
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