Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 126, Issue -, Pages 69-73Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2019.03.001
Keywords
Neuronal migration; Blood vessel; Ventricular-subventricular zone; Neurogenesis; Angiogenesis; Brain regeneration
Categories
Funding
- NEXT [LS104]
- MEXT KAKENHI [22122004, 17H05750, 17H05512]
- JSPS KAKENHI [26250019, 17H01392, JP16H06280, 25111727, 23680041, 17K07114, 18K15372]
- JSPS Program for Advancing Strategic International Networks to Accelerate the Circulation of Talented Researchers [S2704]
- Brain Science Foundation
- Takeda Science Foundation
- Cooperative Study Programs of the National Institute for Physiological Sciences
- Grants-in-Aid for Scientific Research [22122004, 18K15372, 17H05750, 17H01392, 26250019, 25111727, 17H05512, 17K07114, 23680041] Funding Source: KAKEN
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Neurogenesis and angiogenesis share regulatory factors that contribute to the formation of vascular networks and neuronal circuits in the brain. While crosstalk mechanisms between neural stem cells (NSCs) and the vasculature have been extensively investigated, recent studies have provided evidence that blood vessels also play an essential role in neuronal migration in the brain during development and regeneration. The mechanisms of the neuronal migration along blood vessels, referred to as vascular-guided migration, are now being elucidated. The vascular endothelial cells secrete soluble factors that attract and promote neuronal migration in collaboration with astrocytes that enwrap the blood vesgels. In addition, especially in the adult brain, the blood vessels serve as a migration scaffold for adult-born immature neurons generated in the ventricular-sub ventricular zone (V-SVZ), a germinal zone surrounding the lateral ventricles. The V-SVZ-derived immature neurons use the vascular scaffold to assist their migration toward an injured area after ischemic stroke, and contribute to neuronal regeneration. Here we review the current knowledge about the role of vasculature in neuronal migration and the molecular mechanisms controlling this process. While most of this research has been done in rodents, a comprehensive understanding of vasculature-guided neuronal migration could contribute to new therapeutic approaches for increasing new neurons in the brain after injury.
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