Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 20, Issue 10, Pages 642-657Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41580-019-0155-x
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Funding
- RNA Biology Center at the Cancer Science Institute (CSI) of Singapore, National University of Singapore
- Singapore Ministry of Education [MOE2014-T3-1-006]
- Canadian Institutes of Health Research [FDN-154303]
- [NRF2016-CRP001-103 CRP]
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Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved in the regulation of fundamental cellular processes, including transcription, RNA processing, signal transduction cascades, the DNA damage response and liquid-liquid phase separation. Recent studies have provided considerable advances in the development of experimental tools and the identification of clinically relevant PRMT inhibitors. In this review, we discuss the regulation of PRMTs, their various cellular roles and the clinical relevance of PRMT inhibitors for the therapy of neurodegenerative diseases and cancer.
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