Journal
NATURE REVIEWS CLINICAL ONCOLOGY
Volume 16, Issue 11, Pages 669-683Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41571-019-0227-z
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Funding
- US NIH [P50 CA097190]
- University of Pittsburgh Cancer Center support grant [P30CA047904]
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Head and neck cancers are a heterogeneous collection of malignancies of the upper aerodigestive tract, salivary glands and thyroid. In this Review, we primarily focus on the changing therapeutic landscape of head and neck squamous cell carcinomas (HNSCCs) that can arise in the oral cavity, oropharynx, hypopharynx and larynx. We highlight developments in surgical and non-surgical therapies (mainly involving the combination of radiotherapy and chemotherapy), outlining how these treatments are being used in the current era of widespread testing for the presence of human papillomavirus infection in patients with HNSCC. Finally, we describe the clinical trials that led to the approval of the first immunotherapeutic agents for HNSCC, and discuss the development of strategies to decrease the toxicity of different treatment modalities.
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