Journal
NATURE MEDICINE
Volume 25, Issue 7, Pages 1089-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41591-019-0469-4
Keywords
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Funding
- Academy of Finland [139021, 256375, 287675, 296814, 296817, 308254]
- Juho Vainio Foundation
- Paivikki and Sakari Sohlberg Foundation
- Finnish Cultural Foundation
- Yrjo Jahnsson Foundation
- Kuopion seudun hengityssaatio
- European Union [QLK4-CT-2001-00250]
- National Institute for Health and Welfare, Finland
- Alfred P. Sloan Foundation [G-2016-7076]
- Deutsche Zentrum fur Lungenforschung
- Deutsche Forschungsgemeinschaft (DFG) [SFB 1021]
- SCHA [997/8-1]
- GILKUJ-39
- Kuhne Foundation, Schindellegi, Switzerland
- German Research Foundation [MU 891/5-1]
- [82DZL00502]
- [ERC2009-AdG_20090506_250268]
- [LSHB-CT-2006-018996]
- Academy of Finland (AKA) [296817, 308254, 296814, 296817, 308254, 256375, 287675, 296814, 287675, 256375] Funding Source: Academy of Finland (AKA)
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Asthma prevalence has increased in epidemic proportions with urbanization, but growing up on traditional farms offers protection even today(1). The asthma-protective effect of farms appears to be associated with rich home dust microbiota(2,3), which could be used to model a health-promoting indoor microbiome. Here we show by modeling differences in house dust microbiota composition between farm and non-farm homes of Finnish birth cohorts(4) that in children who grow up in non-farm homes, asthma risk decreases as the similarity of their home bacterial microbiota composition to that of farm homes increases. The protective microbiota had a low abundance of Streptococcaceae relative to outdoor-associated bacterial taxa. The protective effect was independent of richness and total bacterial load and was associated with reduced proinflammatory cytokine responses against bacterial cell wall components ex vivo. We were able to reproduce these findings in a study among rural German children(2) and showed that children living in German non-farm homes with an indoor microbiota more similar to Finnish farm homes have decreased asthma risk. The indoor dust microbiota composition appears to be a definable, reproducible predictor of asthma risk and a potential modifiable target for asthma prevention.
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