Journal
NATURAL PRODUCT RESEARCH
Volume 35, Issue 6, Pages 893-899Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1610754
Keywords
Artemisia argyi; sesquiterpenoids; electronic circular dichroism calculations; cytotoxic activity
Categories
Funding
- National Key Research and Development Program of China [2017YFD0201402]
- National Science Fund for Distinguished Young Scholars [81525026]
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A new eudesmane sesquiterpenoid, artemisargin A (1), and two new guaianolide sesquiterpenoids, artemisargins B (2) and C (3), along with three known sesquiterpenoids (4-6), were isolated from Artemisia argyi leaves. Compound 1 showed inhibitory effects on cancer cell growth, especially in BGC-823 cells with an IC50 value of 49.87 mu M.
A new eudesmane sesquiterpenoid, artemisargin A (1), two new guaianolide sesquiterpenoids, artemisargins B (2) and C (3), along with three known sesquiterpenoids (4-6), were isolated from the leaves of Artemisia argyi. Their structures were determined by extensive spectroscopic methods and electronic circular dichroism calculations. Biological evaluation showed that 1 could inhibit the growth of cancer cells, especially in BGC-823 cells with an IC50 value of 49.87 mu M. [GRAPHICS] .
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