Chemical constituents of the aerial parts ofSalvia judaicaBoiss. from Jordan

Investigation of the chemical constituents ofSalvia judaicagrowing wild in Jordan led to the isolation and identification of 15 known compounds. These included: luteolin-3 '-methyl ether (1), indole-3-carboxyaldehyde (2),p-hydroxybenzaldehyde (3), tricin (4), apigenin (5), methyl isoferuloyl-7-(3,4-dihydroxyphenyl) lactate (6), methyl rosmarinate (7), rosmarinic acid (8), salvigenin (9),beta-sitosterol (10), 3 beta, 28-dihydroxyurs-12-ene (11), cirsilineol (12), 2,3-dihydroxyurs-12-en-28-oic acid (13),beta-sitosteryl glucoside (14), and tormentic acid (15). Compounds6and7exhibited strong radical scavenging and chelating activities as compared to alpha-tocopherol and ascorbic acid, compound7showed a 2-fold greater antioxidant activity as compared to compound6. Furthermore, low doses of compounds6and7were able to inhibit the growth of leukemic (HL-60, Jurkat, K562 and CCRF-SB) and solid tumor cells (MCF-7, MDA-MB-231 and Caco-2). Compound7showed a ca. 3-4-fold stronger cytotoxicity against the tested cells as compared to compound6.