New nitrogen-containing metabolites from cultures of rice false smut pathogen Villosiclava virens

Two new nitrogen-containing metabolites methyl N-acetyl-O-(4-acetylphenyl)-L-homoserinate (1), dimethyl (1H-indole-3-carbonyl)-D-glutamate (2), and two new natural products, 1,2-O-isopropylidene-D-mannitol (3), N-acetyl-beta-methyl-L-phenylalanine (4), along with five known compounds (5-9) were isolated from the rice false smut pathogen Villosiclava virens UV-8b cultured in the solid rice medium. The structures were elucidated by spectroscopic analysis and by comparison of their physical and spectroscopic data with the literature. These metabolites were evaluated for their antibacterial and phytotoxic activities. Compounds 5-7 showed weak inhibition against the tested bacteria, while compounds 4-6 and 9 displayed inhibitory activity against the radicle elongation of rice seeds.

Automated summary

New nitrogen-containing metabolites and natural products were isolated from the rice false smut pathogen, Villosiclava virens UV-8b, and evaluated for antibacterial and phytotoxic activities. Some compounds showed weak inhibition against bacteria, while others displayed inhibitory activity against the radicle elongation of rice seeds.