Journal
NATURAL PRODUCT RESEARCH
Volume 35, Issue 7, Pages 1084-1089Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1638384
Keywords
Dasymaschalon rostratum; annonaceae; aristololactam; anticancer activity
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Funding
- Key R&D Projects in Hainan Province -Social Development [ZDYF2018164]
- Project for Scientific Research in Hainan Institution of Higher Learning [Hnky2017-87]
- International S&T cooperation Program of China (ISTCP) [2014DFA40850]
- National Natural Science Foundation of China [21362009, 81360478]
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A novel aristololactam alkaloid, dasymalactam A, and nine known analogues were isolated from Dasymaschalon rostratum roots. These compounds demonstrated weak cytotoxicity against several human cancer cell lines.
A novel aristololactam alkaloid, dasymalactam A (1), together with nine known analogues (2-10), were isolated from the roots of Dasymaschalon rostratum. Their structures were elucidated by IR, NMR and MS spectrums and comparisons with data reported in the literature. All compounds demonstrated weak cytotoxicity against Hela, MCF-7, A-549, MGC-803, and COLO-205 human cancer cell lines. [GRAPHICS] .
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