Journal
NANOMEDICINE
Volume 14, Issue 15, Pages 1946-1971Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2018-0415
Keywords
antioxidant assay; colon targeting; DSS-induced colitis; gastroenterology; glycyrrhizic acid; kinetic models; pH-sensitive nanoparticles; PLGA nanoparticles; sustained release nanoparticles; x-ray photoelectron spectroscopy
Funding
- Higher Education Commission of Pakistan (HEC)
- Higher Education Commission of Pakistan Indigenous program Batch II Phase III
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Aim: To fabricate and evaluate the therapeutic efficacy of glycyrrhizic acid (GA)-loaded pH-sensitive nanoformulations that specifically target and combat mucosal inflammation of the colon. Methods: GA-loaded Eudragit (R) S100/poly-(lactic-co-glycolic acid) nanoparticles were developed through modified double-emulsion evaporation coupled with solvent evaporation coating techniques and analyzed for physicochemical characteristics, surface chemistry, release kinetics, site-retention and therapeutic effectiveness. Results: Nanoparticles have a particle size of approximately 200 nm, high encapsulation efficiency, desired surface chemistry with pH-dependent and sustained drug release behavior following the Gompertz kinetic model. in vivo retention and therapeutic effectiveness in the inflamed colon tissues were confirmed by macroscopic and microscopic indices, cytokine analysis and antioxidant assays. Conclusion: GA-loaded Eudragit S100/poly-(lactic-co-glycolic acid) nanoparticles could efficiently deliver GA to the colon and ameliorate the mucosal inflammation for a prolonged duration. [GRAPHICS] .
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