Journal
NANO LETTERS
Volume 19, Issue 8, Pages 5277-5286Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.9b01735
Keywords
Liquid metals; supernanoparticles; microwave dynamic therapy; microwave thermal therapy
Categories
Funding
- National Natural Science Foundation of China [91859201, 61671435, 81630053]
- National Scientific Foundation Committee of Beijing [JQ18021]
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The cytotoxic reactive oxygen species (ROS) generated by photoactivated sensitizers have been well explored in tumor therapy for nearly half a century, which is known as photodynamic therapy (PDT). The poor light penetration depth severely hinders PDT as a primary or adjuvant therapy for clinical indication. Whereas microwaves (MWs) are advantageous for deep penetration depth, the MW energy is considerably lower than that required for the activation of any species to induce ROS generation. Herein we find that liquid metal (LM) supernanoparticles activated by MW irradiation can generate ROS, such as center dot OH and center dot O-2. On this basis, we design dual-functional supernanoparticles by loading LMs and an MW heating sensitizer ionic liquid (IL) into mesoporous ZrO2 nanoparticles, which can be activated by MW as the sole energy source for dynamic and thermal therapy concomitantly. The microwave sensitizer opens the door to an entirely novel dynamic treatment for tumors.
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