Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 26, Issue 12, Pages 1594-1598Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458519863644
Keywords
Multiple sclerosis; cognitive rehabilitation; endurance exercise; functional connectivity; hippocampus; default-mode network
Categories
Funding
- MS Network Limburg
- Novartis
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Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention (n = 15) and waitlist group (n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.
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