Journal
MOLECULES
Volume 24, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/molecules24152771
Keywords
glycopeptides; hybrid catalyst; asymmetric hydrogen transfer
Funding
- University of Milan-, Piano di sostegno alla Ricerca [2018-LINEA 2]
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The chiral structure of antibiotic vancomycin (Van) was exploited as an innovative coordination sphere for the preparation of an IrCp* based hybrid catalysts. We found that Van is able to coordinate iridium (Ir(III)) and the complexation was demonstrated by several analytical techniques such as MALDI-TOF, UV, Circular dichroism (CD), Raman IR, and NMR. The hybrid system so obtained was employed in the Asymmetric Transfer Hydrogenation (ATH) of cyclic imines allowing to obtain a valuable 61% e.e. (R) in the asymmetric reduction of quinaldine 2. The catalytic system exhibited a saturation kinetics with a calculated efficiency of K-cat/K-M = 0.688 h(-1)mM(-1).
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