Journal
MOLECULAR DIVERSITY
Volume 24, Issue 3, Pages 841-853Publisher
SPRINGER
DOI: 10.1007/s11030-019-09972-1
Keywords
1,5-Disubstituted-1H-tetrazoles; 1,5-DS-1H-Ts; Post-Ugi-azide reaction; Isocyanides; Multicomponent reaction; MCRs
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Funding
- Research Council of Alzahra University
- Iran National Science Foundation (INSF)
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Ugi-azide four-component reaction (UA-4CR) as development on Ugi four-component reaction (U-4CR) is the condensation reaction involving an aldehyde, an amine, an isocyanide, and an azide source. Nowadays, UA-4CR has been employed for the efficient and facile production of 1,5-disubstituted-1H-tetrazoles (1,5-DS-1H-Ts). Interestingly, the combination of 1,5-DS-1H-Ts with suitable post-transformations in a tandem manner results in the construction of various classes of heterocyclic compounds bearing 1,5-DS-1H-T moiety. This review aims to provide the application of diverse post-Ugi-azide reaction in the preparation of differentN-heterocyclic compounds bearing 1,5-DS-1H-T such as substituted and fused 1,5-DS-1H-Ts. [GRAPHICS] .
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