Journal
MOLECULAR CANCER
Volume 18, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12943-019-1041-z
Keywords
Exosome; CircRNA; Exosomal circRNA; Tumor microenvironment; Biomarker
Categories
Funding
- National Natural Science Foundation of China [81560385]
- Medical Scientific and Technological Research Project of Henan Province [201702027]
- Youth Innovation Fund Project of The First Affiliated Hospital of Zhengzhou University [YNQN2017035]
- China Postdoctoral Science Foundation [2017M610462, 2019T120648]
- National Natural Science Foundation of Henan Province [182300410342]
- Health Commission Technology Talents Overseas Training Project of Henan Province [2018140]
Ask authors/readers for more resources
Exosomes have emerged as critical mediators of intercellular communication, both locally and systemically, by regulating a diverse range of biological processes between cells. Circular RNA (circRNA) is a novel member of endogenous noncoding RNAs with widespread distribution and diverse cellular functions. Recently, circular RNAs have been identified for their enrichment and stability in exosomes. In this review, we outline the origin, biogenesis and function of exosomal circRNAs as well as their roles in various diseases. Although their precise roles and mechanisms of gene regulation remain largely elusive, exosomal circRNAs have potential applications as disease biomarkers and novel therapeutic targets.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available