Journal
MINI-REVIEWS IN MEDICINAL CHEMISTRY
Volume 19, Issue 20, Pages 1644-1665Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557519666190722164247
Keywords
Drug delivery; biomedical imaging; photodynamic therapy; Metal-Organic Frameworks (MOFs); Porous Coordination Polymers (PCPs); Photodynamic Therapy (PDT)
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Funding
- Public Research and Capacity Building Projects of Department of Guangdong Province [2017A010103022]
- Natural Science Foundation of Guangdong Province [2017A030313079]
- Featured Innovation Project of Guangdong Province [2017KTSCX083]
- Special Funds for Scientific Technological Innovation of Undergraduates in Guangdong Province [pdjha0218, pdjha0219, pdjh2019b0215, pdjh2019b0219, pdjh2019b0221, pdjha0226, pdjh2019b0222]
- Shenzhen Peacock Plan (Research and Development and Industrialization of in vitro Diagnostic Nanomaterials for Tumors) [KQTD2016022920325195]
- Science Foundation of Guangdong Medical University [ZYDM040, ZYDM041, ZYDM016, ZYDM017]
- Group-type special support project for Education Talents in Universities [4SG19045G, G619080-438]
- Funds for PHD researchers of Guangdong Medical University in 2019
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Metal-Organic Frameworks (MOFs) have aroused great interest in the field of nanoscience and nanotechnology particularly in biomedical domains, such as Drug Delivery System (DDS), Biomedical Imaging (BI) and Photodynamic Therapy (PDT). As an emerging material, MOFs possess extraordinarily high surface area, controllable particle size and good biocompatibility. With extraordinary flexibility in the selection of organic and inorganic components, MOFs can rationally be tuned to obtain the materials having versatile structures and porosities. MOFs can serve as ideal vehicles for DDS, BI and PDT through modification and function. In this review, we summarized the design and synthetic strategies for preparing MOFs and introduced their recent advanced usage in DDS, BI and PDT. Finally, the prospect and future challenges of these nanomaterials are also documented.
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