Journal
MICROCHIMICA ACTA
Volume 186, Issue 7, Pages -Publisher
SPRINGER WIEN
DOI: 10.1007/s00604-019-3577-4
Keywords
Electrochemical; Nanocomposites; Sensor; Guanine; Adenine; Fetal bovine serum; Mouse whole blood
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Funding
- National Natural Science Foundation of China [21778047, 21675138]
- Department of Science and Technology of Shandong Province of China [2018GSF116011, GG201709290055]
- Yantai City of China [2017ZH093]
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Guanine and adenine in blood samples can be detected by using an electrochemical sensor based on the use of manganese dioxide (MnO2) nanosheets and ionic liquid functionalized graphene (IL-GR) bound to a polydopamine (PDA) membrane. Both guanine and adenine undergo aredox reaction on the surface of the modified electrode. Cyclic voltammetry and differential pulse voltammetry were used to evaluate the electrochemical behavior of a glassy carbon electrode (GCE) modified with PDA/MnO2/IL-GR. The sensor allows for individual as well as simultaneous determination of guanine and adenine. The working voltage of differential pulse voltammetry at which data were acquired to establish the calibration plot: 0.6-1.2V for guanine, 0.8-1.4V for adenine, 0.4-1.4V for mixture of guanine and adenine. A wide detection range (10-300M), low detection limits (guanine: 0.25M; adenine: 0.15M), selectivity and reproducibility are demonstrated. The modified GCE was successfully applied to the analysis of guanine and adenine in spiked fetal bovine serum and mouse whole blood samples.
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