Journal
METABOLISM-CLINICAL AND EXPERIMENTAL
Volume 99, Issue -, Pages 102-112Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.metabol.2019.153949
Keywords
Muscle mass; Body composition; Metabolic dysregulation; Children
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Funding
- Stollery Children's Hospital Foundation through the Women and Children's Health Research Institute
- Alberta Diabetes Institute
- 2018 Alberta SPOR Graduate Studentship in Patient-Oriented Research - Alberta Innovates
- 2018 Alberta SPOR Graduate Studentship in Patient-Oriented Research - Canadian Institutes of Health Research
- CNPq
- Emerging Leaders in the Americas Program - Government of Canada
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Skeletal muscle is recognized as a tissue with high metabolic capacity given its key roles in glucose and lipid metabolism. Although low muscle mass has been associated with metabolic disorders in adults, it is not clear if this body composition phenotype is related to metabolic health status earlier in life. In this review, we aim to clarify whether having low muscle mass is associated with increased risk of metabolic dysregulation in the pediatric population. Fifteen original articles investigating the relationship between body composition measures of muscle mass and single or clustered metabolic risk factors in children and adolescents were critically evaluated. Despite a growing body of evidence supporting low muscle mass as a risk factor for metabolic health in children and adolescents, conflicting associations were reported. Differences in body composition techniques, muscle mass indices, and clinical methods used to assess metabolic biomarkers may have contributed to a lack of a consistent conclusion. Moreover, most studies did not control for potential biological and lifestyle confounders. Future studies using precise, reproducible techniques to evaluate body composition and metabolic biomarkers are required to determine the implications of low muscle mass on metabolic health during childhood and adolescence. (C) 2019 Elsevier Inc. All rights reserved.
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