Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 74, Issue -, Pages 187-190Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2015.08.008
Keywords
Diabetes mellitus; Calpain; Diabetic nephropathy; Diabetic cardiomyopathy; Diabetic retinopathy
Funding
- Science Foundation of Heilongjiang Province [H201431]
- National Natural Science Foundation of China [81100574]
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Diabetes mellitus (DM) is associated with acute and chronic complications that cause major morbidity and significant mortality. Calpains, a family of Ca(2+)-dependent cytosolic cysteine proteases, can modulate their substrates' structure and function through limited proteolytic activity. Calpain is a ubiquitous calcium-sensitive protease that is essential for normal physiologic function. However, alterations in calcium homeostasis lead to pathologic activation of calpain in diabetes mellitus. Since not much is known on the relationship between calpain and diabetes mellitus, this review outlines the contribution of calpain to chronic complications of diabetes mellitus, such as diabetic cardiomyopathy, diabetic nephropathy and diabetic retinopathy. (C) 2015 Elsevier Masson SAS. All rights reserved.
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