Poorly controlled type 2 diabetes with no progression of diabetes-related complications and low levels of advanced glycation end products A Case report

Rationale: Previous studies have suggested that increased levels of advanced glycation end products (AGEs) and soluble receptor for AGE (sRAGE) are associated with diabetes-related complications. However, there is little evidence on the association between long-term levels of AGEs and sRAGE and progression of diabetes-related complications. Patient concerns: A 64-year-old man had poorly controlled type 2 diabetes, obesity, smoking, hypertension, and dyslipidemia. He had many risk factors for diabetes-related complications. Diagnosis: Despite poor glycemic control over 15 years, the patient did not exhibit diabetes-related complications. Interventions: We examined serum AGEs (CEL and MG-H1) and sRAGE levels in this patient over the past 10 years. Outcomes: The patient maintained low serum AGEs and sRAGE levels. Lessons: AGEs and sRAGE levels may be associated with long-term development of diabetes-related complications.