Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 180, Issue -, Pages 117-128Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2019.03.007
Keywords
Aging; Biological age; Animal models; Sex differences; Epigenetics; Deficit accumulation
Categories
Funding
- Glenn Foundation for Medical Research
- NIH [R37 AG028730, R01 AG019719, R01 DK100263]
- Epigenetics Seed Grant from Department of Genetics, Harvard Medical School [601139_2018]
- NHMRC CJ Martin biomedical fellowship [GNT1122542]
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Even though they would have great benefit across research and clinical fields, currently there are no accepted biomarkers of frailty. Cross-sectional studies in humans have identified promising candidates including inflammatory markers such as IL-6, immune markers such as WBC count, clinical markers such as albumin, endocrine markers such as vitamin D, oxidative stress markers such as isoprostanes, proteins such as BDNF and epigenetic markers such as DNA methylation, but there are limitations to the current state of the research. Future approaches to the identification of frailty biomarkers should include longitudinal studies, studies using animal models of frailty, studies incorporating novel biomarkers combined into composite panels, and studies investigating sex differences and potential overlap between markers of biological age and frailty.
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