Journal
MATRIX BIOLOGY
Volume 84, Issue -, Pages 4-16Publisher
ELSEVIER
DOI: 10.1016/j.matbio.2019.07.005
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Funding
- Australian Postgraduate Award
- Australian Government Research Training Program Stipend Scholarship
- Australian Research Council
- RSL Australia
- National Health
- and Medical Research Council
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Elastic fibers are an essential component of the extracellular matrix where they provide structural integrity and elastic recoil in a number of important tissues. A major constituent of these fibers is elastin, an insoluble metabolically stable polymer formed via extensive crosslinking of the monomeric precursor tropoelastin. Research over the past few decades has shown that tropoelastin possesses unique structural features that differ from both intrinsically disordered and globular proteins. This review details the advances in our understanding of tropoelastin's structural properties and illustrates how these dictate its biological function. (C) 2019 Elsevier B.V. All rights reserved.
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