MgO enables enhanced bioactivity and antimicrobial activity of nano bioglass for bone tissue engineering application

Nanobioglass is perceived as an effective biomaterial for bone tissue regeneration because of its predominant osteoconductivity since it was developed. The present work reports the synthesis of 58S nanobioglass (nBg) by sol-gel technique and MgO incorporated nBg by adding pure MgO nanoparticles with different concentrations. The prepared MgO, bioglass (Bg) and MgO-bioglass (MBg) nanoparticles were characterized by FESEM which revealed the particle size in the range 25-65nm for MgO, 40-70nm for Bg and 9-35nm for MBg nanoparticles. XRD results suggested that the synthesis of pure form of MgO nanoparticles and amorphous phase of Bg as well as MBg. In-vitro bioactivity and the antimicrobial test revealed that the presence of MgO improves antimicrobial activity and apatite layer formation ability of Bg. The study has demonstrated that the sol-gel derived MBg might be a potential biomaterial platform for bone tissue regeneration.