Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 99, Issue -, Pages 1123-1132Publisher
ELSEVIER
DOI: 10.1016/j.msec.2019.02.072
Keywords
Osteonecrosis of femoral head; Bone marrow stromal stem cells; Bio-Gide collagen membrane; Porous tantalum; Full-thickness articular cartilage defect
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Funding
- National Natural Science Foundation of China [81371942]
- National Science and Technology Support Program [2012BAI17802]
- General Foundation of Liaoning Province Education Bureau [L2015021]
- Public Welfare Industry Research Projects of Ministry of Health of the People's Republic of China
- Dalian Science and Technology Bureau [2013J21DW004]
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Osteonecrosis of the femoral head (ONFH) results in collapse of the femoral head and rapid destruction of the hip joint. The repair of post-collapse articular cartilage and subchondral bone is challenging. We interrupted the blood supply to the femoral head and established a full-thickness articular defect animal model after ONFH was determined via X-ray. Porous tantalum and a Bio-Gide collagen membrane, co-cultured with bone marrow mesenchymal stem cells (BMSCs) in vitro, were implanted into the defect zone to repair the full-thickness articular defect. Hyaline cartilage was detected on top of the tantalum near the edge of the defect 12 weeks post-operatively. Porous tantalum and a Bio-Gide collagen membrane with BMSCs may repair full-thickness articular defects if the blood supply can be reconstructed in the post-collapse stage of ONFH.
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