Journal
MARINE DRUGS
Volume 17, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/md17080445
Keywords
marine sponge; Halichondria vansoesti; trisulfated steroids; topsentiasterol sulfates; halistanol sulfates; anticancer activity; PSA expression; glucose uptake
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Funding
- RFBR [18-53-54002 Viet-a]
- VAST [QTRU01.04/18-19]
- RSF (Russian Science Foundation) [18-74-10028]
- Russian Science Foundation [18-74-10028] Funding Source: Russian Science Foundation
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Seven new unusual polysulfated steroids-topsentiasterol sulfate G (1), topsentiasterol sulfate I (2), topsentiasterol sulfate H (3), bromotopsentiasterol sulfate D (4), dichlorotopsentiasterol sulfate D (8), bromochlorotopsentiasterol sulfate D (9), and 4 beta-hydroxyhalistanol sulfate C (10), as well as three previously described-topsentiasterol sulfate D (7), chlorotopsentiasterol sulfate D (5) and iodotopsentiasterol sulfate D (6) have been isolated from the marine sponge Halichondria vansoesti. Structures of these compounds were determined by detailed analysis of 1D- and 2D-NMR and HRESIMS data, as well as chemical transformations. The effects of the compounds on human prostate cancer cells PC-3 and 22Rv1 were investigated.
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