Journal
MARINE DRUGS
Volume 17, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/md17080446
Keywords
genome mining; global regulator; LaeA; overexpression; Penicillium dipodomyis; sorbicillinoids
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Funding
- Fundamental Research Funds for the Central Universities [201941001]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1606403]
- Marine S& T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao) [2018SDKJ0401-2]
- Taishan Scholar Youth Expert Program in Shandong Province [tsqn201812021]
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Overexpression of the global regulator LaeA in a marine-derived fungal strain of Penicillium dipodomyis YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new ones named 10,11-dihydrobislongiquinolide (1) and 10,11,16,17-tetrahydrobislongiquinolide (2), as well as four known analogues, bislongiquinolide (3), 16,17-dihydrobislongiquinolide (4), sohirnone A (5), and 2 ',3 '-dihydrosorbicillin (6). The results support that the global regulator LaeA is a useful tool in activating silent gene clusters in Penicillium strains to obtain previously undiscovered compounds.
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