Journal
MARINE DRUGS
Volume 17, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/md17080433
Keywords
Penicillium sp; lactones; antibacterial activity; insecticidal activity
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Funding
- National Natural Science Foundation of China [31760093, 21462015, 41866005, 21662012]
- Key Research and Development Program of Hainan Province [ZDYF2018183]
- National Natural Science Foundation of Hainan Province [218MS045]
- Program for Innovative Research Team in University [IRT-16R19]
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Three new lactones penicilactones A-C (1-3) were obtained from the mangrove-derived fungus Penicillium sp. TGM112. Their structures and absolute configurations were determined by detailed NMR, MS spectroscopic data, Mo-2(OAc)(4)-induced electronic circular dichroism (ECD), and circular dichroism (CD) spectroscopy. Compound 1 showed antibacterial activity against Staphylococcus aureus with an MIC value of 6.25 mu g/mL. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with the LC50 value of 78.5 (+/- 0.58) mu g/mL.
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