Journal
APPLIED SURFACE SCIENCE
Volume 383, Issue -, Pages 240-247Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2016.04.181
Keywords
oxide nanoparticles; Oleic acid; Magnetic hyperthermia; Magnetic resonance imaging
Categories
Funding
- FEDER funds through the COMPETE Program
- National Funds through FCT-Portuguese Foundation for Science and Technology [POCI-01-0145-FEDER-007688, UID/CTM/50025]
- Associate Laboratory for Green Chemistry LAQV - national funds from FCT/MEC [UID/QUI/50006/2013]
- ERD Funder the PT Partnership Agreement [POCI-01-0145-FEDER-007265]
- FCT [UID/Multi/04349/2013, SFRH/BD/81711/2011, SFRH/BD/84628/2012]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/81711/2011] Funding Source: FCT
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Iron oxide nanoparticles (Fe3O4, IONPs) are promising candidates for several biomedical applications such as magnetic hyperthermia and as contrast agents for magnetic resonance imaging (MRI). However, their colloidal stability in physiological conditions hinders their application requiring the use of biocompatible surfactant agents. The present investigation focuses on obtaining highly stable IONPs, stabilized by the presence of an oleic acid bilayer. Critical aspects such as oleic acid concentration and pH were optimized to ensure maximum stability. NPs composed of an iron oxide core with an average diameter of 9 nm measured using transmission electron microscopy (TEM) form agglomerates with an hydrodynamic diameter of around 170 nm when dispersed in water in the presence of an oleic acid bilayer, remaining stable (zeta potential of 120 mV). Magnetic hyperthermia and the relaxivities measurements show high efficiency at neutral pH which enables their use for both magnetic hyperthermia and MRI. (C) 2016 Elsevier B.V. All rights reserved.
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