Journal
APPLIED SURFACE SCIENCE
Volume 370, Issue -, Pages 270-278Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2016.02.124
Keywords
Chitosan; Surface grafting; Citric acid; Chemical modification; Biomineralization
Categories
Funding
- National Science Foundation of China [11532003, 51273072]
- Project of Natural Science Research of Higher Education Institutions of Jiangsu Province [15KJB310001]
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We develop a novel chitosan-citric acid film (abbreviated as CS-CA) suitable for biomedical applications in this study. In this CS-CA film, the citric acid, which is a harmless organic acid has been extensively investigated as a modifying agent on carbohydrate polymers, was cross-linked by 1-Ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) onto the surface of chitosan (CS) film. Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) confirms the graft copolymerization of the modified chitosan film (CS-CA). Surface wettability, moisturizing performance, the capacity of mineralization in vitro and biocompatibility of the films were characterized. After modification, this CS-CA film has good hydrophilicity. It is very evident that the citric acid grafting treatment significantly promotes the biomineralization of the chitosan based substrates. Cell experiments show that the MC3T3-E1 osteoblasts can adhere and proliferate well on the surface of CS-CA film. This CS-CA film, which can be prepared in large quantities and at low cost, should have potential application in bone tissue engineering. (C) 2016 Elsevier B.V. All rights reserved.
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