Journal
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
Volume 18, Issue -, Pages 401-407Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.bspc.2015.02.014
Keywords
Pediatric obstructive sleep apnea; Airflow; Oximetry; Spectral analysis; At-home assessment
Categories
Funding
- Proyecto Cero on Aging from Fundacion General CSIC
- Ministerio de Economia y Competitividad [TEC2011-22987]
- Consejeria de Educacion de la Junta de Castilla y Leon [VA059U13]
- FEDER
- SEPAR
- Consejeria de Educacion de la Junta de Castilla y Leon
- European Social Fund
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The obstructive sleep apnea syndrome (OSAS) greatly affects both the health and the quality of life of children. Therefore, an early diagnosis is crucial to avoid their severe consequences. However, the standard diagnostic test (polysomnography, PSG) is time-demanding, complex, and costly. We aim at assessing a new methodology for the pediatric OSAS diagnosis to reduce these drawbacks. Airflow (AF) and oxygen saturation (SpO(2)) at-home recordings from 50 children were automatically processed. Information from the spectrum of AF was evaluated, as well as combined with 3% oxygen desaturation index (ODI3) through a logistic regression model. A bootstrap methodology was conducted to validate the results. OSAS significantly increased the spectral content of AF at two abnormal frequency bands below (BW1) and above (BW2) the normal respiratory range. These novel bands are consistent with the occurrence of apneic events and the posterior respiratory overexertion, respectively. The spectral information from BW1 and BW2 showed complementarity both between them and with ODI3. A logistic regression model built with 3 AF spectral features (2 from BW1 and 1 from BW2) and ODI3 achieved (mean and 95% confidence interval): 85.9% sensitivity [64.5-98.7]; 87.4% specificity [70.2-98.6]; 86.3% accuracy [74.9-95.4]; 0.947 area under the receiver-operating characteristics curve [0.826-1]; 88.4% positive predictive value [72.3-98.5]; and 85.8% negative predictive value [65.8-98.5]. The combination of the spectral information from two novel AF bands with the ODI3 from SpO(2) is useful for the diagnosis of OSAS in children. (C) 2015 Elsevier Ltd. All rights reserved.
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