Predicting essential proteins from protein-protein interactions using order statistics

Many computational methods have been proposed to predict essential proteins from protein-protein interaction (PPI) networks. However, it is still challenging to improve the prediction accuracy. In this study, we propose a new method, esPOS (essential proteins Predictor using Order Statistics) to predict essential proteins from PPI networks. Firstly, we refine the networks by using gene expression information and subcellular localization information. Secondly, we design some new features, which combine the protein predicted secondary structure with PPI network. We show that these new features are useful to predict essential proteins. Thirdly, we optimize these features by using a greedy method, and combine the optimized features by order statistic method. Our method achieves the prediction accuracy of 0.76-0.79 on two network datasets. (C) 2019 Elsevier Ltd. All rights reserved.