Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 141, Issue 24, Pages 9527-9532Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b04711
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Funding
- NSFC [21525208, U1804283]
- Henan Normal University [5101034011009]
- Central Plains Scholars and Scientists Studio Fund [2018002]
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Enantiomeric access to pentatomic biaryls is challenging due to their relatively low rotational barrier. Reported herein is the mild and highly enantioselective synthesis of 2,3'-biindolyls via underexplored integration of C-H activation and alkyne cyclization using a unified chiral Rh(III) catalyst. The reaction proceeded via initial C-H activation followed by alkyne cyclization. A chiral rhodacyclic intermediate has been isolated from stoichiometric C-H activation, which offers direct mechanistic insight.
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