Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 141, Issue 29, Pages 11398-11403Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b05363
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Funding
- Miami University
- Ministry of Science and Technology of the Republic of China
- MOST [107-2113-M-006-008-MY2]
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We report herein a highly efficient Cu-catalyzed protocol for the conversion of aliphatic carboxylic acids to the corresponding difluoromethylated analogues. This robust, operationally simple and scalable protocol tolerates a variety of functional groups and can convert a diverse array of acid-containing complex molecules to the alkyl-CF2H products. Mechanistic studies support the involvement of alkyl radicals.
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