Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 141, Issue 29, Pages 11358-11362Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b03566
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Funding
- UK Engineering and Physical Sciences Research Council [EPSRC EP/M008238/1, EPSRC EP/P027067/1, EPSRC EP/L015978/1]
- European Union [642192]
- EPSRC [EP/P027067/1, EP/M008258/1] Funding Source: UKRI
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A water-soluble self-assembled supramolecular (Fe4L4)-L-II tetrahedron binds to single stranded DNA, mismatched DNA base pairs, and three-way DNA junctions. Binding of the coordination cage quenches fluorescent labels on the DNA strand, which provides an optical means to detect the interaction and allows the position of the binding site to be gauged with respect to the fluorescent label. Utilizing the quenching and binding properties of the coordination cage, we developed a simple and rapid detection method based on fluorescence quenching to detect unpaired bases in double-stranded DNA.
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