Journal
BIOMEDICAL RESEARCH-TOKYO
Volume 36, Issue 2, Pages 143-153Publisher
BIOMEDICAL RESEARCH PRESS LTD
DOI: 10.2220/biomedres.36.143
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Funding
- Research Program of Intractable Disease - Ministry of Health, Labor, and Welfare (MHLW) of Japan
- Japanese Ministry of Education, Culture, Sports, Science and Technology [17591060]
- Kanazawa Medical University Research Foundation [S2004-16, S2007-5]
- Kanazawa Medical University [K2011-7, AR2012-06]
- High-Tech Research Center of Kanazawa Medical University [H2011-11]
- Grants-in-Aid for Scientific Research [17591060] Funding Source: KAKEN
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Proliferated IgG4(+) plasma cells are polyclonal, suggesting that the pathogenesis of IgG4-related disease (IgG4-RD) involves upstream events related to the regulation of IgG4 expansion. We hypothesized that lymphoid follicle formation may play an important role in the pathogenesis of IgG4-RD. Using various antibodies, especially against monocyte, macrophage, and follicular dendritic cell markers, we immunohistochemically assessed the distribution of immune cells in lymphoid follicles. Pathological findings of tissue samples from patients with IgG4-RD (n = 22), reactive hyperplasia (n = 3), multicentric Castleman's disease (n = 3), and Sjogren's syndrome (n = 13) were analyzed. CD14-positive lymphoid follicles were observed only in patients with IgG4-RD, and CD14-positive cells were identified as follicular dendritic cells by multicolor immunohistochemistry. There were few differences in the distributions of other cell types between the IgG4-RD and control groups. The presence of CD14(+) follicular dendritic cells in lymphoid follicles may play a pathophysiological role in IgG4-RD.
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