Journal
JOURNAL OF PHYSIOLOGY-LONDON
Volume 598, Issue 9, Pages 1695-1705Publisher
WILEY
DOI: 10.1113/JP276524
Keywords
STIM; ORAI; calcium; store depletion; conformational change
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [16/12505-8] Funding Source: FAPESP
- NIAID NIH HHS [R01 AI109842, R01 AI040127, R01 AI084167, R56 AI109842] Funding Source: Medline
- NIH HHS [AI040127, AI084167, AI109842] Funding Source: Medline
- São Paulo Research Foundation [2016/12505-8] Funding Source: Medline
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The control of calcium influx at the plasma membrane by endoplasmic reticulum (ER) calcium stores, a process common to invertebrates and vertebrates, is central to physiological calcium signalling and cellular calcium balance. Stromal interaction molecule 1 (STIM1) is a calcium sensor and regulatory protein localized to the ER. ORAI1 is a calcium channel in the plasma membrane (PM). In outline, STIM1 senses an ER-luminal calcium decrease, relocalizes to ER-PM junctions, and recruits and gates ORAI1 channels. Recent work, reviewed here, has offered detailed insight into the process of sensing and communicating ER calcium-store depletion, and particularly into the STIM1 conformational change that is the basis for communication between the ER and the PM.
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