Journal
BIOMEDICAL RESEARCH-TOKYO
Volume 36, Issue 2, Pages 103-107Publisher
BIOMEDICAL RESEARCH PRESS LTD
DOI: 10.2220/biomedres.36.103
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Funding
- KAKENHI scientific research grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan [19380164, 26450400]
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [26450400, 19380164] Funding Source: KAKEN
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Nfkbiz is an inhibitor of nuclear factor KB (IkB) protein localized to the nucleus. We previously found that Nfkbiz gene-disrupted mice showed atopic dermatitis-like lesion, implying the important role of Nfkbiz in skin homeostasis. The purpose of this study was to examine the effect of interferon (IFN)-gamma on Nfkbiz expression in keratinocytes. IFN-gamma induced Nfkbiz expression at a comparable level to IL-1. Promoter analysis revealed that interferon-stimulated response element (ISRE) located in the Nfkbiz promoter region is important for responding to the stimulation. Interestingly, IFN-gamma and IL-1 displayed synergism in terms of inducing Nfkbiz expression. By using selective inhibitors, we found that Janus activated kinase (JAK) 1 and nuclear factor (NF)-kB are important for Nfkbiz expression after IFN-gamma stimulation and for synergism between IFN-gamma and ILL These findings indicate a possible important role of Nfkbiz in modulating the progression of inflammatory diseases in which IFN-gamma and IL-1 are abundant.
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