Journal
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
Volume 10, Issue 15, Pages 4185-4191Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.9b01735
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Funding
- NSFC [11722543, U1867215, 81800943]
- Fundamental Research Funds for the Central Universities [2042019kf0312]
- Suzhou Key Industrial Technology Innovation Project [SYG201828]
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The treatment of massive bone defects is still a significant challenge for orthopedists. Here we have engineered synthetic porous AuPd alloy nanoparticles (pAuPds) as a hyperthermia agent for in situ bone regeneration through photothermal therapy (PTT). After being swallowed by cells, pAuPds produced a mild localized heat (MLH) (40-43 degrees C) under the irradiation of a near-infrared laser, which can greatly accelerate cell proliferation and bone regeneration. Almost 97% of the cranial defect area (8 mm in diameter) was covered by the newly formed bone after 6 weeks of PTT. RNA sequencing analysis was used to obtain insight into the molecular mechanism of the MLH on cell proliferation and bone formation. These results demonstrated that the Wnt signaling pathway was involved in the MLH. This Letter provides a unique strategy with mild heat stimulation and high efficiency for in situ bone regeneration.
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