Journal
APPLIED SPECTROSCOPY REVIEWS
Volume 52, Issue 3, Pages 249-266Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/05704928.2016.1226182
Keywords
Articular cartilage; infrared spectroscopy; microscopy; near-infrared spectroscopy; osteoarthritis; Raman spectroscopy
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Funding
- Academy of Finland [268378]
- European Research Council under the European Union's Seventh Framework Programme (FP)/ERC [336267]
- University of Oulu
- Academy of Finland (AKA) [268378, 268378] Funding Source: Academy of Finland (AKA)
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Articular cartilage is a connective tissue that is located at the ends of long bones. Type II collagen, proteoglycans, water, and chondrocytes are the main constituents of articular cartilage. Osteoarthritis, the most common joint disease in the world, causes degenerative changes in articular cartilage tissue. Fourier transform infrared, Raman, and near infrared spectroscopic techniques offer versatile tools to assess biochemical composition and quality of articular cartilage. These vibrational spectroscopic techniques can be used to broaden our understanding about the compositional changes during osteoarthritis, and they also hold promise in disease diagnostics. In this article, the current literature of articular cartilage spectroscopic studies is reviewed.
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