Related references
Note: Only part of the references are listed.Allosteric Agonism of α7 Nicotinic Acetylcholine Receptors: Receptor Modulation Outside the Orthosteric Site
Alican Gulsevin et al.
MOLECULAR PHARMACOLOGY (2019)
Macroscopic and Microscopic Activation of α7 Nicotinic Acetylcholine Receptors by the Structurally Unrelated Allosteric Agonist-Positive Allosteric Modulators (ago-PAMs) B-973B and GAT107
Marta Quadri et al.
MOLECULAR PHARMACOLOGY (2019)
Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model
Joseph Newcombe et al.
MOLECULAR PHARMACOLOGY (2018)
New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on alpha 7 nAChRs
Deniz Bagdas et al.
CURRENT NEUROPHARMACOLOGY (2018)
Beyond the Channel: Metabotropic Signaling by Nicotinic Receptors
Nadine Kabbani et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2018)
Structural principles of distinct assemblies of the human α4β2 nicotinic receptor
Richard M. Walsh et al.
NATURE (2018)
B-973, a Novel α7 nAChR Ago-PAM: Racemic and Asymmetric Synthesis, Electrophysiological Studies, and in Vivo Evaluation
Sumanta Garai et al.
ACS MEDICINAL CHEMISTRY LETTERS (2018)
B-973, a novel piperazine positive allosteric modulator of the α7 nicotinic acetylcholine receptor
Debra J. Post-Munson et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2017)
Effects of BMS-902483, an α7 nicotinic acetylcholine receptor partial agonist, on cognition and sensory gating in relation to receptor occupancy in rodents
Rick L. Pieschl et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2017)
Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1β via Different Combinations of Nicotinic Acetylcholine Receptor Subunits α7, α9 and α10
Anna Zakrzewicz et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2017)
The α7 nicotinic acetylcholine receptor positive allosteric modulator attenuates lipopolysaccharide-induced activation of hippocampal IκB and CD11b gene expression in mice
Muzaffar Abbas et al.
DRUG DISCOVERIES AND THERAPEUTICS (2017)
Differential α4(+)/(-)β2 Agonist-binding Site Contributions to α4β2 Nicotinic Acetylcholine Receptor Function within and between Isoforms
Linda M. Lucero et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
The 7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain
Deniz Bagdas et al.
BRITISH JOURNAL OF PHARMACOLOGY (2016)
Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION
Nicole A. Horenstein et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
X-ray structure of the human α4β2 nicotinic receptor
Claudio L. Morales-Perez et al.
NATURE (2016)
Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective
Natalia D. Andersen et al.
NEUROPHARMACOLOGY (2016)
The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor
Roger L. Papke et al.
NEUROPHARMACOLOGY (2015)
Structurally Similar Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors Exhibit Five Distinct Pharmacological Effects
JasKiran K. Gill-Thind et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Therapeutic Potential of α7 Nicotinic Acetylcholine Receptors
Daniel Bertrand et al.
PHARMACOLOGICAL REVIEWS (2015)
Merging old and new perspectives on nicotinic acetylcholine receptors
Roger L. Papke
BIOCHEMICAL PHARMACOLOGY (2014)
The Activity of GAT107, an Allosteric Activator and Positive Modulator of α7 Nicotinic Acetylcholine Receptors (nAChR), Is Regulated by Aromatic Amino Acids That Span the Subunit Interface
Roger L. Papke et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Similar activity of mecamylamine stereoisomers in vitro and in vivo
Roger L. Papke et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2013)
Expeditious Synthesis, Enantiomeric Resolution, and Enantiomer Functional Characterization of (4-(4-Bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): An Allosteric Agonist-Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptors
Ganesh A. Thakur et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Effects of alpha 7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models
Kelen Freitas et al.
NEUROPHARMACOLOGY (2013)
Acute Activation, Desensitization and Smoldering Activation of Human Acetylcholine Receptors
Barbara G. Campling et al.
PLOS ONE (2013)
Microwave-assisted expeditious and efficient synthesis of cyclopentene ring-fused tetrahydroquinoline derivatives using three-component Povarov reaction
Abhijit R. Kulkarni et al.
TETRAHEDRON LETTERS (2013)
EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors
Jos Prickaerts et al.
NEUROPHARMACOLOGY (2012)
Intrinsically Low Open Probability of α7 Nicotinic Acetylcholine Receptors Can Be Overcome by Positive Allosteric Modulation and Serum Factors Leading to the Generation of Excitotoxic Currents at Physiological Temperatures
Dustin K. Williams et al.
MOLECULAR PHARMACOLOGY (2012)
A Series of α7 Nicotinic Acetylcholine Receptor Allosteric Modulators with Close Chemical Similarity but Diverse Pharmacological Properties
JasKiran K. Gill et al.
MOLECULAR PHARMACOLOGY (2012)
Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: Advantages and limitations
Dustin K. Williams et al.
BIOCHEMICAL PHARMACOLOGY (2011)
Creating an α7 Nicotinic Acetylcholine Recognition Domain from the Acetylcholine-binding Protein CRYSTALLOGRAPHIC AND LIGAND SELECTIVITY ANALYSES
Akos Nemecz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Unraveling the High- and Low-Sensitivity Agonist Responses of Nicotinic Acetylcholine Receptors
Kasper Harpsoe et al.
JOURNAL OF NEUROSCIENCE (2011)
RG3487, a Novel Nicotinic alpha 7 Receptor Partial Agonist, Improves Cognition and Sensorimotor Gating in Rodents
Tanya L. Wallace et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)
Investigation of the Molecular Mechanism of the α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator PNU-120596 Provides Evidence for Two Distinct Desensitized States
Dustin K. Williams et al.
MOLECULAR PHARMACOLOGY (2011)
Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist
Shu-Xing Li et al.
NATURE NEUROSCIENCE (2011)
Cysteine accessibility analysis of the human alpha7 nicotinic acetylcholine receptor ligand-binding domain identifies L119 as a gatekeeper
Roger L. Papke et al.
NEUROPHARMACOLOGY (2011)
Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site
JasKiran K. Gill et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The neuronal nicotinic α4β2 receptor has a high maximal probability of being open
Ping Li et al.
BRITISH JOURNAL OF PHARMACOLOGY (2010)
Working with OpusXpress: Methods for high volume oocyte experiments
Roger L. Papke et al.
METHODS (2010)
Cholinergic control of inflammation
M. Rosas-Ballina et al.
JOURNAL OF INTERNAL MEDICINE (2009)
Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor
Ramin Faghih et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Activation and Desensitization of Nicotinic α7-type Acetylcholine Receptors by Benzylidene Anabaseines and Nicotine
Roger L. Papke et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
The Selective α7 Agonist GTS-21 Attenuates Cytokine Production in Human Whole Blood and Human Monocytes Activated by Ligands for TLR2, TLR3, TLR4, TLR9, and RAGE
Mauricio Rosas-Ballina et al.
MOLECULAR MEDICINE (2009)
A cog in cognition: How the α7 nicotinic acetylcholine receptor is geared towards improving cognitive deficits
Steven C. Leiser et al.
PHARMACOLOGY & THERAPEUTICS (2009)
Positive Allosteric Modulation of the α7 Nicotinic Acetylcholine Receptor: Ligand Interactions with Distinct Binding Sites and Evidence for a Prominent Role of the M2-M3 Segment
Daniel Bertrand et al.
MOLECULAR PHARMACOLOGY (2008)
Roles of accessory subunits in α4β2*nicotinic receptors
Alexandre Kuryatov et al.
MOLECULAR PHARMACOLOGY (2008)
Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site
Gareth T. Young et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
It is not either/or: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood
Marina R. Picciotto et al.
PROGRESS IN NEUROBIOLOGY (2008)
Distinct profiles of α7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes
Jens Halvard Gronlien et al.
MOLECULAR PHARMACOLOGY (2007)
Selective α7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis
Valentin A. Pavlov et al.
CRITICAL CARE MEDICINE (2007)
Selective alpha 7 nicotinic acetylcholine receptor ligands
Anatoly Mazurov et al.
CURRENT MEDICINAL CHEMISTRY (2006)
A novel positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor:: In vitro and in vivo characterization
RS Hurst et al.
JOURNAL OF NEUROSCIENCE (2005)
Conservation within the RIC-3 gene family - Effectors of mammalian nicotinic acetylcholine receptor expression
S Halevi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Alternate stoichiometries of α4β2 nicotinic acetylcholine receptors
ME Nelson et al.
MOLECULAR PHARMACOLOGY (2003)
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
H Wang et al.
NATURE (2003)
Activation and inhibition of native neuronal alpha-bungarotoxin-sensitive nicotinic ACh receptors
VV Uteshev et al.
BRAIN RESEARCH (2002)
Comparative pharmacology of rat and human α7 nAChR conducted with net charge analysis
RL Papke et al.
BRITISH JOURNAL OF PHARMACOLOGY (2002)
Development of nicotinic drug therapy for cognitive disorders
ED Levin et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2000)
Mixed nicotinic-muscarinic properties of the alpha 9 nicotinic cholinergic receptor
M Verbitsky et al.
NEUROPHARMACOLOGY (2000)
Share Paper
