Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 16, Pages 10518-10525Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b01463
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- China Scholarship Council
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The expedient and stereoselective syntheses of small libraries of trifunctionalized cyclobutane scaffolds bearing an acid, an amine, and a third functional group are described. Starting from a single precursor, the readily available protected derivative of all-cis-2-amino-3-hydroxycyclobutane-1-carboxylic acid, cis-trans stereoisomers are obtained following an S(N)2-type reaction, while all-trans stereoisomers are obtained using the same strategy preceded by a C1 epimerization reaction.
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