Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 20, Pages 12871-12880Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b01538
Keywords
-
Categories
Funding
- CSIR, New Delhi
- UGC, New Delhi
- CSIR [HCP019/MLP0148]
Ask authors/readers for more resources
A highly efficient and regioselective Rh(III)-catalyzed protocol for C8-bromination and amidation of quinoline N-oxide was developed. The transformation was found to be successful up to gram scale with excellent functional group tolerance and wide substrate scope. The mechanistic study revealed five-membered rhodacycle with quinoline N-oxide as a key intermediate for regioselective C8-functionalization. In addition, NFSI (N-fluorobis-(phenylsulfonyl)-imide) was explored as an amidating reagent for C8-amidation of quinoline N-oxide for the first time.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available