Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 17, Pages 10953-10961Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b01564
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- Health Fellowship Foundation
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The first total synthesis of anmindenol A is described in four steps. A notable feature of the synthetic route includes the efficient construction of the 3,10-dialkylsubstituted benzofulvene core via a stereoselective vinylogous Stork enamine aldol condensation. The strategy provided a blueprint for the practical preparation of derivatives with modifications in the C-10 alkyl substituents. The novel derivatives inhibited nitric oxide production in stimulated RAW 264.7 macrophage cells.
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