4.7 Article

L-(-)-Quebrachitol as a Ligand for Selective Copper(0)-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 12, Pages 8160-8167

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b00997

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Funding

  1. Liaoning Provincial Natural Science Foundation of China [201602707]
  2. Discipline Construction Program of Shenyang Pharmaceutical University [52134606]
  3. Program of Yunnan Science and Technology Department [2017jkys03]

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L-(-)-Quebrachitol (QCT) has been found as a ligand of copper powder for selective N-arylation of nitrogen-containing heterocycles with aryl halides. Furthermore, another potential catalytic system (copper powder/QCT/t-BuOK) was successfully adapted to unactivated aryl chlorides.

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