Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 84, Issue 20, Pages 12904-12912Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b01603
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Funding
- Ministry of Science and Technology of China [2017YFA0206903]
- National Natural Science Foundation of China [91427303, 21861132004]
- Strategic Priority Research Program of the Chinese Academy of Science [XDB17000000]
- Key Research Program of Frontier Sciences of the Chinese Academy of Science [QYZDY-SSW-JSC029]
- K. C. Wong Education Foundation
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The functionalization of aliphatic C-H bonds is both a major challenge and a desirable goal in organic synthesis. Here, we describe the successful arylation of unactivated alkanes with heteroarenes by using iridium polypyridyl complexes as the photocatalyst and persulfate as the HAT catalyst precursor under visible-light irradiation. This reaction features good functional group tolerance and broad scope with regard to both alkane and heteroarene substrates (37 examples), which allows direct access to alkyl-substituted N-heteroarenes, a key structural motif in natural products and bioactive molecules.
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