Journal
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
Volume 61, Issue 10, Pages 806-811Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JOM.0000000000001676
Keywords
copper; exposure time; healthy subjects; inflammation; welding; zinc
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Funding
- Institution for Statutory Accident Insurance and Prevention in the woodworking and metalworking industry (BGHM), Hannover, Germany
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Introduction: Inhalation of copper and zinc containing brazing fumes (2.5 mg/m(3) for 6 hours) is able to induce asymptomatic systemic inflammation which is supposed to be connected with an increased risk for cardiovascular disease. In this study it was investigated if inflammation can be prevented by reducing the exposure time. Methods: A total of 15 healthy male subjects were exposed to such brazing fumes in a crossover design for 3, 4, and 5 hours in randomized order. Before and 24 hours after exposure, blood samples were taken and c-reactive protein (CRP) as marker for an acute phase reaction was measured. Results: Five-hour exposure induced an increase of CRP, whereas the shorter exposure times did not result in a significant inflammatory reaction. Conclusions: Reducing daily exposure times below 5 hours is able to prevent systemic inflammatory reactions.
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