Journal
JOURNAL OF NATURAL PRODUCTS
Volume 82, Issue 7, Pages 1930-1934Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00312
Keywords
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Funding
- National Institutes of Health [U19A1109673, U19A1142720]
- NIH [P41GM103399, S10RR02781S10RR08438 S10RR023438S10RR025062S10RR029220]
- University of Wisconsin-Madison
- NSF [DMB-8415048, OIA-9977486, BIR-9214394]
- USDA
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Here we report the discovery of two new 3-acetamido-4-hydroxybenzoate esters, bulbiferates A (1) and B (2), isolated from Microbulbifer sp. cultivated from the marine tunicate Ecteinascidia turbinata. The structures of 1 and 2 were determined by analysis of 2D NMR and MS data. Additionally, three synthetic analogues (3-5), differing in ester sizes/lengths, were prepared for the purposes of evaluating potential structure activity relationships; no clear correlations tying ester lengths to activity were evident. Bulbiferates A (1) and B (2) demonstrated antibacterial activity against both Escherichia coli (E. coli) and methicillin-sensitive Staphylococcus aureus (MSSA), whereas the synthetic analogues 3 and 4 displayed activity only against MSSA.
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