Journal
JOURNAL OF NATURAL PRODUCTS
Volume 82, Issue 7, Pages 1874-1885Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00120
Keywords
-
Funding
- Ministry of Education, Science and Technological Development of Serbia [172061]
Ask authors/readers for more resources
Structural elucidation of a new triquinane sesquiterpenoid, presilphiperfolane-7 alpha,8 alpha-diol, 1a, isolated from Pulicaria vulgaris, was accomplished by combining solvent-induced removal of chemical shift degeneracy and computational (DFT-GIAO) prediction of NMR spectra with the analysis of H-1 NMR splitting patterns. In addition to extensive NMR experiments (in 10 different solvents), MS, and FTIR, the identity of la was also confirmed by chemical transformations. The applied approach can facilitate structural elucidation of organic molecules and decrease the probability of an erroneous identification, permitting an unambiguous stereochemical elucidation and full NMR assignment. The pharmacological/toxicological profile of la was evaluated in several different models.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available